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Library of Congress Cataloging-in-Publication Data


Co-Editors


THOMAS ALBRECHT, PhD

Section: Virology

Professor, Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas

SAMUEL BARON, MD

Section: Virology

Professor and Chairman, Department of Microbiology and Immunology, Professor, Department of Internal Medicine, and Associate Dean for Research Development and Planning, University of Texas Medical Branch at Galveston, Galveston, Texas

GILBERT CASTRO, PhD

Section: Parasitology

Professor, Department of Integrative Biology, Associate Dean, Special Projects, University of Texas Health Science Center at Houston, Houston, Texas

ROBERT B. COUCH, MD

Section: Introduction to Infectious Diseases

Professor and Chairman, Department of Microbiology and Immunology; Professor and Chief, Division of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, Texas

CHARLES PATRICK DAVIS, MD, Ph.D.

Section: Bacteriology

North East Methodist Hospital, Department of Emergency Medicine, San Antonio, Texas

FERDINANDO DIANZANI, MD

Section: Virology

Professor and Chairman, Institute of Virology, University of Rome Medical School, Rome, Italy; Adjunct Professor, Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas

MICHAEL R. MCGINNIS, PhD

Section: Mycology

Professor, Department of Pathology, Associate Director of WHO Collaborating Center for Tropical Diseases, Director of Medical Mycology Research Center, University of Texas Medical Branch at Galveston, Galveston, Texas

DAVID W. NIESEL, PhD

Section: Bacteriology

Professor, Department of Microbiology and Immunology, University of, Texas Medical Branch at Galveston, Galveston, Texas

LEROY J. OLSON, PhD

Section: Parasitology

Professor and Vice Chairman, Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas

GAIL L. WOODS, MD

Section: Bacteriology

Professor, Department of Pathology, Director of Clinical Microbiology, University of Texas Medical Branch at Galveston, Galveston, Texas


Authors


THOMAS ALBRECHT, PhD

Professor, Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, Texas

JEFFREY W. ALMOND, PhD

Professor, Department of Microbiology University of Reading and Head, School of Animal and Microbial Sciences, England

MICHELLE J. ALFA, PhD

Assistant Professor, Department of Medical Microbiology, University of Manitoba and Assistant Director, Department of Medical Microbiology, St. Boniface General Hospital, Winnipeg, Manitoba, Canada

G. G. ALTON, DVMS

Former Senior Principal Research Scientist, C.S.I.R.O. Animal Health Research Laboratory, Commonwealth Scientific and Industrial Research Organization, Parkville, Australia

RAZA ALY, PhD

Professor, Department of Dermatology, University of California, San Francisco School of Medicine, San Francisco, California

DAVID M. ASHER, MD

National Institute of Neurological Disorders and Stroke, Division of Intramural Research, National Institutes of Health, Bethesda, Maryland

ELLEN J. BARON, PhD

Associate Professor of Medicine, Diplomate, ABMM, University of California, Los Angeles, Pacific Palisades, California

SAMUEL BARON, MD

Professor and Chairman, Department of Microbiology and Immunology, Professor, Department of Internal Medicine, University of Texas Medical Branch at Galveston, Galveston, Texas

DERRICK BAXBY, PhD, MRCPath

Senior Lecturer, Department of Medical Microbiology, University of Liverpool; Honorary Microbiologist, Royal Liverpool Hospital, Liverpool, England

YECHIEL BECKER, PhD

Carolyn Jane Bandheim Chair, Department of Molecular Virology, Faculty of Medicine The Hebrew University of Jerusalem, Jerusalem, Israel

NEIL R. BLACKLOW, MD

Richard M. Haidack Distinguished Professor in Medicine, Molecular Genetics and Microbiology, and Chairman, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts

MARTIN J. BLASER, MD

Professor and Chairman of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee

ISTVAN BOLDOGH, DM&B, PhD

Associate Professor Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, Texas

GEORGE H. BOWDEN, PhD

Professor of Oral Surgery, Department of Oral Biology, University of Manitoba, Winnipeg, Manitoba, Canada

PHILIP S. BRACHMAN, MD

Professor, Emory University, Rollins School of Public Health, Atlanta, Georgia

JANET S. BUTEL, PhD

Professor and Head, Division of Molecular Virology, Baylor College of Medicine, Houston, Texas

JASON CALHOUN, MD

Professor and Chairman, Department of Orthopaedic Surgery and Rehabilitation, The University of Texas Medical Branch, Galveston, Texas

GILBERT A. CASTRO, PhD

Professor, Department of Integrative Biology, Associate Dean, Special Projects, University of Texas Medical School at Houston, Houston, Texas

MILES CLOYD, PhD

Professor, Department of Microbiology & Immunology, The University of Texas Medical Branch at Galveston, Galveston, Texas

GARRY T. COLE, PhD

Professor and Chairman, Department of Microbiology, Medical College of Ohio, Toledo, Ohio

FRANK M. COLLINS, PhD, DSc

Member, Trudeau Institute Inc., Saranac Lake, New York

ROBERT B. COUCH, MD

Professor and Chairman, Department of Microbiology and Immunology; Professor and Chief, Division of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, Texas

JAMES M. CRUTCHER, MD, MPH

Staff Researcher, Malaria Program, Naval Medical Research Institute, Rockville, Maryland

JOHN H. CROSS, PhD

Professor, Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland

PURUSHOTHAMA V. DASARAJU, MD

Fellow in Infectious Diseases, Departments of Medicine and Pediatrics, University of Kansas Medical Center, Kansas City, Kansas

CHARLES PATRICK DAVIS, MD, PhD

North East Methodist Hospital, Department of Emergency Medicine, San Antonio, Texas

ERIK DE CLERCQ, MD, PhD

Professor of Microbiology and Biochemistry and Chairman, Department of Microbiology, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium

FERDINANDO DIANZANI, MD

Professor and Chairman, Institute of Virology, University of Rome Medical School, Rome, Italy; Adjunct Professor, Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, Texas

DENNIS M. DIXON, PhD

Mycology Program Officer, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland

WALTER DOERFLER, MD

Professor of Genetics, Institute of Genetics, University of Cologne, Cologne, Federal Republic of Germany

BARBARA L. DOUGHTY, PhD

Professor, Department of Immunoparasitology, Texas A&M University, College of Veterinary Medicine, College Station, Texas

J. P. DUBEY, MVSC, PhD

Microbiologist, Zoonotic Disease Laboratory, Livestock and Poultry Sciences Institute, United States Department of Agriculture, Beltsville, Maryland

GISELA ENDERS, MD

Professor and Honorary Professor for Clinical Virology, Department of Virology, Faculty for Human Medicine, Philipps University, Marburg; Honorary Professor, Faculty for Virology and Microbiology, University of Hohemheim; Head, Institut fur Medizinische Virologies und Infektions and epidemiologie, Stuttgart, Federal Republic of Germany

DOLORES G. EVANS, PhD

Professor, Veterans Affairs Medical Center, (Gastroenterology) Houston, Texas

DOYLE J. EVANS, JR., PhD

Associate Professor, Veterans Affairs Medical Center, (Gastroenterology) Houston, Texas

HEINZ FELDMANN, MD

Research Fellow, Institute of Virology, Phillipps-University Marburg, Marburg Germany

FRANK FENNER, MD

Professor Emeritus, John Curtin School of Medical Research, Australian National University, Canberra, Australia

SYDNEY M. FINEGOLD, MD

Professor and Staff Physician, Infectious Disease Section, Veterans Affairs Medical Center, West Los Angeles, California

HORST FINGER, MD

Director (Retired), Institut fuer Hygiene und Laboratoriums- medizin, Klinikum Krefeld, Germany

RICHARD A. FINKELSTEIN, PhD

Curators' Professor, Millsap Distinguished Professor, and Chairman, Department of Molecular Microbiology and Immunology, University of Missouri - Columbia School of Medicine, Columbia, Missouri

W. ROBERT FLEISCHMANN, JR., PhD

Professor, Department of Microbiology and Immunology,
The University of Texas Medical Branch at Galveston, Galveston, Texas

MICHAEL FONS, PhD

Senior Scientist, Gene Medicine, Inc., The Woodlands, Texas

J. R. L. FORSYTH, MD

Director, Microbiological Diagnostic Unit, University of Melbourne, Melbourne, Australia

TIMOTHY J. FOSTER, PhD

Associate Professor, Department of Microbiology, Moyne Institute of Preventive Medicine, University of Dublin, Trinity College, Dublin, Ireland

HANS R. GELDERBLOM, MD

Director and Professor, Robert Koch-Institut, Berlin, Germany

RALPH A. GIANNELLA, MD

Mark Brown Professor of Medicine and Director, Division of Digestive Diseases, University of Cincinnati Medical Center, Cincinnati, Ohio

CLARENCE J. GIBBS, JR., PhD

Deputy Chief, Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland

KAREN L. GOLDENTHAL, MD

Director, Division of Vaccines and Related Products Applications, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Rockville, Maryland

ARMOND S. GOLDMAN, MD

Professor, Departments of Pediatrics, Microbiology and Immunology, Human Biological Chemistry and Genetics, and Pathology, The University of Texas Medical Branch at Galveston, Galveston, Texas

THOMAS D. GOOTZ, PhD

Principal Research Scientist, Central Research Division, Pfizer, Inc, Groton, Connecticut

SHERWOOD L. GORBACH, MD

Professor, Department of Community Health and Medicine, Tufts University School of Medicine, Boston, Massachusetts

M. NEAL GUENTZEL, PhD

Professor , Division of Life Sciences, University of Texas at San Antonio; Professor, Department of Microbiology, University of Texas Medical School at San Antonio, San Antonio, Texas

THOMAS L. HALE, MD

Chief, Department of Enteric Infections, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, DC

DAVID J. HENTGES, PhD

Professor and Chairman, Department of Microbiology and Immunology, Texas Tech University Health Sciences Center School of Medicine, Lubbock, Texas

DONALD HEYNEMAN, PhD

Professor Emeritus,of Parasitology, Department of Epidemiology and Biostatistics, University of California, San Francisco School of Medicine, San Francisco, California

HERBERT HOF, MD

Professor, Institute of Medical Microbiology and Hygiene, Faculty of Clinical Medicine, University of Heidelberg; Director, Institute of Medical Microbiology and Hygiene of the Municipal Hospital, Mannheim, Federal Republic of Germany

STEPHEN L. HOFFMAN, MD, DTMH

Director, Malaria Program, Naval Medical Research Institute, Bethesda, Maryland

RANDALL K. HOLMES, MD, PhD

Professor and Chairman, Department of Microbiology, University of Colorado Health Sciences Center, Denver, Colorado

WALTER T. HUGHES, MD

Professor and Chairman, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee

BARBARA H. IGLEWSKI, PhD

Professor and Chair, Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York

MICHAEL G. JOBLING, PhD

Research Assistant Professor, Department of Microbiology, University of Colorado Health Sciences Center, Denver Colorado

RICHARD T. JOHNSON, MD

Professor and Director, Departments of Neurology and Microbiology and Neuroscience, The Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, Maryland

RUSSELL C. JOHNSON, PhD

Professor, Department of Microbiology, University of Minnesota Medical School-Minneapolis, Minneapolis, Minnesota

PETER JURTSHUK, JR., PhD

Professor, Department of Biology, College of Natural Science and Mathematics, University of Houston, Houston, Texas

ALBERT Z. KAPIKIAN, MD

Head, Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland

DORIS S. KELSEY, MD

Associate Professor, Department of Pediatrics, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina

GERALD T. KEUSCH, MD

Chief, Division of Geographic Medicine, Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts

KWANG-SHIN KIM, PhD

Associate Professor, Department of Microbiology, New York University School of Medicine, New York, New York

HANS-DIETER KLENK, MD

Professor, Institute of Virology, Philipps-University Marburg, Marburg, Germany

GARY R. KLIMPEL, PhD

Professor, Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, Texas

GEORGE S. KOBAYASHI, PhD

Professor, Department of Medicine, Infectious Diseases Division, Washington University School of Medicine, St. Louis, Missouri

CARL HEINZ WIRSING von KOENIG, MD

Director, Institut fuer Hygiene und Laboratoriumsmedizin Klinikum Krefeld, Krefeld, Germany

CHIEN LIU, MD

Professor Emeritus of Medicine and of Pediatrics, Departments of Medicine and Pediatrics, University of Kansas Medical Center, Kansas City, Kansas

WALTER J. LOESCHE, DMD, PhD

Professor, Department of Dentistry, University of Michigan School of Dentistry; Professor, Department of Microbiology, University of Michigan School of Medicine, Ann Arbor, Michigan

JOAN C. M. MACNAB, PhD

Senior Scientist, Medical Research Council Virology Unit; Honorary Lecturer, University of Glasgow, Glasgow, Scotland

JON T. MADER, MD

Professor, Department of Internal Medicine, Division of Infectious Diseases, Department of Pathology, Adjunctive Professor, Department of Orthopaedic Surgery, Member, Marine Biomedical Institute, Chief of Marine Medicine, The University of Texas Medical Branch at Galveston, Galveston, Texas

AUGUSTO JULIO MARTINEZ, MD

Professor, Department of Pathology, Division of Neuropathology, University of Pittsburgh, Presbyterian University Hospital, Pittsburgh, Pennsylvania

DAVID J. McCLAIN, MD

Virology Division, U.S. Army Medical Research Institute for Infectious Diseases, Ft. Detrick, Maryland

MICHAEL R. McGINNIS, PhD

Professor, Department of Pathology, Associate Director of WHO Collaborating Center for Tropical Diseases, Director of Medical Mycology Research Center, The University of Texas Medical Branch at Galveston, Galveston, Texas

DAVID N. McMURRAY, PhD

Professor, Department of Medical Microbiology and Immunology, Texas A & M University College of Medicine, College Station, Texas

ERNEST A. MEYER, ScD

Professor, Department of Molecular Microbiology and Immunology, Oregon Health Sciences University School of Medicine, Portland, Oregon

STEPHEN A. MORSE, MSPH, PhD

Director, Division of Sexually Transmitted Diseases, Laboratory Research National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.

KAREN MIDTHUN, MD

Senior Medical Reviewer, Division of Vaccines and Related Products Applications, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Rockville, Maryland

JOHN R. MURPHY, PhD

Professor of Medicine (Molecular Genetics) Section of Biomolecular Medicine, Boston University Medical Center, The University Hospital, Boston, Massachusetts

DANIEL M. MUSHER, MD

Professor, Departments of Medicine and Microbiology and Immunology, Chief, Infectious Diseases Section, Baylor College of Medicine; Veterans Administration Hospital, Houston, Texas

STEVEN MYINT, MD, MRCP, MHSM

Professor of Clinical Microbiology, Department of Microbiology & Immunology, University of Leicester, Lei, England

HAROLD C. NEU, MD

Professor, Departments of Medicine and Pharmacology, Columbia University College of Physicians and Surgeons, New York, New York

LEROY J. OLSON, PhD

Professor, and Vice-Chairman, Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, Texas

DAVID ONIONS, PhD, MRCVS

Professor, Head of Department of Veterinary Pathology, The Veterinary School, University of Glasgow, Glasgow, Scotland

PAUL D. PARKMAN, MD

President, Parkman Associates, Kensington, Maryland

GARY PATOU, BSC, MB, BS, MRCPath

Lecturer, Department of Medical Microbiology, University College and Middlesex School of Medicine, London, England

MARIA JEVITZ PATTERSON, MD, PhD

Professor, Departments of Microbiology and Pediatrics, Michigan State University, East Lansing, Michigan

JOHN R. PATTISON, MA, DM, FRCPath

Dean of Medical School and Faculty of Clinical Sciences, University College London Medical School, London, England

LAWRENCE L. PELLETIER, JR., MD

Chief, Medical Service, Wichita Veterans Affairs Medical Center & Professor and Vice-Chairman, Department of Internal Medicine, University of Kansas Medical School of Medicine-Wichita, Wichita, Kansas

GUILLERMO I. PEREZ-PEREZ, DSc

Research Associate Professor of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee

JOHNNY W. PETERSON, PhD

Professor, Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, Texas

CHARLES J. PFAU, PhD

Professor of Biology, Rensselaer Polytechnic Institute, Troy, New York

DAVID D. PORTER, MD

Professor, Department of Pathology, University of California, Los Angeles, UCLA School of Medicine, Los Angeles, California

BELLUR S. PRABHAKAR, PhD

Professor, Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, Texas

ALAN S. RABSON, MD

Director, Division of Cancer Biology, Diagnosis, and Centers, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

JUSTIN D. RADOLF, MD

Associate Professor of Internal Medicine and Microbiology, Department of Internal Medicine, Division of Infectious diseases, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas

SHMUEL RAZIN, PhD

Professor and Pro-Dean, Faculty of Medicine, Department of Membrane and Ultrastructure Research, The Hebrew University-Hadassah Medical School, Jerusalem, Israel

JOHN B. ROBBINS, MD

Chief, Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland

BERNARD ROIZMAN, ScD

Joseph Regenstien Distinguished Service Professor of Virology, Marjorie B. Kovler Viral Oncology Laboratories, The University of Chicago, Chicago, Illinois

ALLAN R. RONALD, MD, FRCPC, FACP

H.E. Sellers Professor and Head, Department of Internal Medicine, University of Manitoba Winnipeg, Manitoba, Canada

CHARLES E. RUPPRECHT, VMD, MS, PhD

Chief, Rabies Section, Centers for Disease Control & Prevention, Atlanta, Georgia

MILTON R. J. SALTON, ScD

Professor, Department of Microbiology, New York University School of Medicine, New York, New York

ALAN L. SCHMALJOHN, PhD

Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland

RACHEL SCHNEERSON, MD

Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland

JOHN RICHARD SEED, PhD

Professor, Department of Epidemiology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina

ROBERT E. SHOPE, MD

Professor of Pathology and Microbiology and Immunology, Center for Tropical Diseases, The University of Texas Medical Branch at Galveston, Galveston, Texas

WILLIAM A. SODEMAN, JR., MD

Professor of Medicine and Chief, Division of Gastroenterology Department of Internal Medicine, Medical College of Ohio, Toledo, Ohio

SHOUSUN C. SZU, PhD

Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland

PETER C. B. TURNBULL, BSc, MS, PhD

Anthrax Section, Division of Biologics, Public Health Laboratory Service Centre for Applied Microbiology and Research, Salisbury, Wiltshire, England

DAVID A. J. TYRRELL, MD, DRCP, FRS

CAMR (Centre for Applied Microbiology & Research) Porton Down, Salisbury, Wiltshire, United Kingdom

DEREK WAKELIN, PhD, DSc

Dean of the Faculty of Life Science, University of Nottingham, Nottingham, England

DAVID H. WALKER, MD

Professor and Chairman, Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, Texas

THOMAS J. WALSH, MD

Senior Investigator, Head, Mycology Unit Section of Infectious Diseases, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

JOHN A. WASHINGTON, MD

Chairman, Department of Clinical Pathology, Vice Chairman Division of Pathology and Laboratory Medicine, Head, Section of Microbiology, Cleveland Clinic Foundation, Cleveland, Ohio

CAROL L. WELLS, PhD

Professor, Departments of Laboratory Medicine and Pathology and Surgery, University of Minnesota, Minneapolis, Minnesota

RICHARD J. WHITLEY, MD

Professor, of Pediatrics, Microbiology and Medicine, University of Alabama School of Medicine, Birmingham, Alabama

TRACY D. WILKINS, PhD

Strobants Professor of Agricultural Biotechnology, Department of Biochemistry and Anaerobic Microbiology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia

WASHINGTON C. WINN, JR., MD

Professor, Department of Pathology, University of Vermont College of Medicine; Director, Clinical Microbiology Laboratory, Medical Center Hospital of Vermont, Burlington, Vermont

ROBERT G. YAEGER, PhD

Professor (Retired), Department of Tropical Medicine, School of Public Health and Tropical Medicine; and Professor (Retired), Department of Medicine, School of Medicine, Tulane University, New Orleans, Louisiana

MARGUERITE YIN-MURPHY, MA, PhD, Dip Bact

Associate Professor, Department of Microbiology, Faculty of Medicine, National University of Singapore; Director, WHO Collaborating Centre for Virus Reference & Research (Enterovirus) and Head, WHO National Laboratory for Poliomyelitis Eradication, Singapore

RODRIGO A. ZELEDÒN, ScD

Professor (Research Program in Tropical Disease) Escuela De Medicina Veterinaria, Programa De Investigación en Enfermedades Tropicales (PIET), Universidad Nacional, Heredia, Costa Rica

KATHRYN C. ZOON, PhD

Director, Center for Biologics Evaluation and Research Food and Drug Administration Rockville, Maryland

ARIE J. ZUCKERMAN, MD, DSc, FRCP, FRCPath

Professor of Medical Microbiology in the University of London, and Dean, Royal Free Hospital School of Medicine London, England